SIRT-IN-3


Catalog No. Size PriceQuantity
M28189-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

SIRT-IN-3 is a potent SIRT inhibitor, with an IC50 of 17 μM for SIRT1. SIRT-IN-3 shows about 4-fold and 14-fold selectivity for SIRT1 over SIRT2 and SIRT3, respectively (IC50 of 74 μM and 235 μM for SIRT2 and SIRT3, respectively).

Product information

CAS Number: 1211-19-4

Molecular Weight: 212.25

Formula: C13H12N2O

Chemical Name: 2-(phenylamino)benzamide

Smiles: NC(=O)C1=CC=CC=C1NC1C=CC=CC=1

InChiKey: JKWQUMKCVDUICQ-UHFFFAOYSA-N

InChi: InChI=1S/C13H12N2O/c14-13(16)11-8-4-5-9-12(11)15-10-6-2-1-3-7-10/h1-9,15H,(H2,14,16)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (1177.86 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

SIRT-IN-3 (Compound 7) (30-300 μM; 8 hours) causes p53 acetylation in in HCT116 cells.

Products are for research use only. Not for human use.

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