Description
Cdc7-IN-1 (Compound 13) is a highly potent, selective and ATP competitive inhibitor of Cdc7 kinase, with an IC50 value of 0.6 nM at 1 mM ATP and with slow off-rate characteristics. Cdc7-IN-1 potently inhibits Cdc7 activity in cancer cells, and effectively induces cell death.
Product information
CAS Number: 1402055-25-7
Molecular Weight: 409.82
Formula: C21H16ClN3O4
Chemical Name: ethyl 2-[(2-chlorophenyl)amino]-4-hydroxy-5-{[(3Z)-3H-pyrrolo[2,3-b]pyridin-3-ylidene]methyl}furan-3-carboxylate
Smiles: CCOC(=O)C1C(O)=C(/C=C2\C=NC3=NC=CC=C\23)OC=1NC1=CC=CC=C1Cl
InChiKey: MNEODYFHQBZJNQ-ZRDIBKRKSA-N
InChi: InChI=1S/C21H16ClN3O4/c1-2-28-21(27)17-18(26)16(10-12-11-24-19-13(12)6-5-9-23-19)29-20(17)25-15-8-4-3-7-14(15)22/h3-11,25-26H,2H2,1H3/b12-10+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 5.2 mg/mL (12.69 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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