Description
AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding, with an IC50 of 3.2 μM.
Product information
CAS Number: 1256094-31-1
Molecular Weight: 279.22
Formula: C13H8F3N3O
Chemical Name: 2-(pyridin-2-yl)-6-(trifluoromethoxy)-1H-1,3-benzodiazole
Smiles: FC(F)(F)OC1=CC2NC(=NC=2C=C1)C1=CC=CC=N1
InChiKey: JSNWHSDKJSOXET-UHFFFAOYSA-N
InChi: InChI=1S/C13H8F3N3O/c14-13(15,16)20-8-4-5-9-11(7-8)19-12(18-9)10-3-1-2-6-17-10/h1-7H,(H,18,19)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (358.14 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
AI-10-47 (10 μM) weakly inhibits CBFβ-RUNX binding. AI-10-47 significantly inhibits ME-1, TUR, M0-91, THP-1 and U937 cell growth.
Products are for research use only. Not for human use.
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