Description
JH-LPH-33, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. JH-LPH-33 displays outstanding antibiotic activity with a MIC value of 0.66 μg/mL.
Product information
CAS Number: 2414590-04-6
Molecular Weight: 487.92
Formula: C21H21ClF3N3O3S
Chemical Name: 1-[5-({4-[3-chloro-5-(trifluoromethyl)phenyl]piperazin-1-yl}sulfonyl)-2,3-dihydro-1H-indol-1-yl]ethan-1-one
Smiles: CC(=O)N1CCC2=CC(=CC=C12)S(=O)(=O)N1CCN(CC1)C1=CC(Cl)=CC(=C1)C(F)(F)F
InChiKey: PDEIRNVIXFZSSJ-UHFFFAOYSA-N
InChi: InChI=1S/C21H21ClF3N3O3S/c1-14(29)28-5-4-15-10-19(2-3-20(15)28)32(30,31)27-8-6-26(7-9-27)18-12-16(21(23,24)25)11-17(22)13-18/h2-3,10-13H,4-9H2,1H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
JH-LPH-33 displays IC50 values of 0.026 μM against K. pneumoniae LpxH and 0.046 μM against E. coli LpxH, respectively. JH-LPH-33 potently inhibits bacterial growth at 1.6 μg/mL and displayes a MIC value of >64 μg/mL against E. coli.
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.