ShK-Dap22

ShK-Dap22 is a potent Kv1.3-specific immunosuppressive Polypeptide. ShK-Dap22 is a selective Kv1.3 channel blocker with IC50s of 23 pM, 1.8 nM, 10.5 nM, 37 nM, and 39 nM for mKv1.3, mKv1.1, hKv1.6, mKv1.4, and rKv1.2 channels, respectively.

Product information

CAS Number: 220384-25-8

Molecular Weight: 4012.69

Formula: C166H268N54O48S7

Chemical Name: 31-[2-(2-amino-5-carbamimidamidopentanamido)-3-hydroxypropanamido]-10,51,87-tris(4-aminobutyl)-75-(aminomethyl)-60,96-dibenzyl-19,28-bis(butan-2-yl)-4,54,69-tris(3-carbamimidamidopropyl)-93-(2-carbamoylethyl)-25-(carboxymethyl)-22,39,48,102-tetrakis(1-hydroxyethyl)-7,63,81-tris(hydroxymethyl)-72-[(4-hydroxyphenyl)methyl]-84-[(1H-imidazol-4-yl)methyl]-99-methyl-66-(2-methylpropyl)-78-[2-(methylsulfanyl)ethyl]-3,6,9,12,18,21,24,27,30,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80,83,86,89,92,95,98,101,104-dotriacontaoxo-33,34,106,107,110,111-hexathia-2,5,8,11,17,20,23,26,29,37,40,43,46,49,52,55,58,61,64,67,70,73,76,79,82,85,88,91,94,97,100,103-dotriacontaazatetracyclo[55.47.4.4⁴⁵,⁹⁰.0¹³,¹⁷]112ne-36-carboxylic acid

Smiles: CC(C)CC1NC(=O)C(CCCNC(N)=N)NC(=O)C(CC2=CC=C(O)C=C2)NC(=O)C(CN)NC(=O)C(CCSC)NC(=O)C(CO)NC(=O)C(CC2=CNC=N2)NC(=O)C(CCCCN)NC(=O)C2CSSCC3NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)C(CSSCC(NC(=O)C(CCCNC(N)=N)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(NC(=O)C(NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CSSCC(NC(=O)C(NC(=O)CNC3=O)C(C)O)C(O)=O)NC(=O)C(CO)NC(=O)C(N)CCCNC(N)=N)C(C)CC)C(C)O)C(C)CC)C(=O)NC(C(C)O)C(=O)NC(C)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCC(N)=O)C(=O)N2)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CO)NC1=O)C(C)O

InChiKey: PFWOJTLVNOZSGQ-UHFFFAOYSA-N

InChi: InChI=1S/C166H268N54O48S7/c1-13-81(5)123-156(261)202-107(65-122(232)233)145(250)218-128(87(11)228)160(265)216-124(82(6)14-2)161(266)220-58-31-43-119(220)155(260)196-95(38-22-25-52-168)135(240)205-110(70-222)147(252)191-99(42-30-57-185-166(179)180)136(241)209-117-77-273-272-75-115-152(257)193-97(40-28-55-183-164(175)176)132(237)189-96(39-23-26-53-169)139(244)217-127(86(10)227)159(264)212-113(131(236)186-68-121(231)214-125(84(8)225)158(263)213-118(162(267)268)78-275-274-76-116(153(258)215-123)211-150(255)109(69-221)204-130(235)93(171)36-27-54-182-163(173)174)73-270-271-74-114(208-137(242)100(48-49-120(172)230)194-141(246)103(61-88-32-17-15-18-33-88)197-129(234)83(7)188-157(262)126(85(9)226)219-154(117)259)151(256)192-94(37-21-24-51-167)133(238)201-106(64-91-67-181-79-187-91)144(249)207-111(71-223)148(253)195-101(50-59-269-12)138(243)203-108(66-170)146(251)199-105(63-90-44-46-92(229)47-45-90)142(247)190-98(41-29-56-184-165(177)178)134(239)198-102(60-80(3)4)140(245)206-112(72-224)149(254)200-104(143(248)210-115)62-89-34-19-16-20-35-89/h15-20,32-35,44-47,67,79-87,93-119,123-128,221-229H,13-14,21-31,36-43,48-66,68-78,167-171H2,1-12H3,(H2,172,230)(H,181,187)(H,186,236)(H,188,262)(H,189,237)(H,190,247)(H,191,252)(H,192,256)(H,193,257)(H,194,246)(H,195,253)(H,196,260)(H,197,234)(H,198,239)(H,199,251)(H,200,254)(H,201,238)(H,202,261)(H,203,243)(H,204,235)(H,205,240)(H,206,245)(H,207,249)(H,208,242)(H,209,241)(H,210,248)(H,211,255)(H,212,264)(H,213,263)(H,214,231)(H,215,258)(H,216,265)(H,217,244)(H,218,250)(H,219,259)(H,232,233)(H,267,268)(H4,173,174,182)(H4,175,176,183)(H4,177,178,184)(H4,179,180,185)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

ShK-Dap22 suppresses T cell activation in vitro. ShK-Dap22, at subnanomolar concentrations, suppresses anti-CD3 induced human T-lymphocyte [3H]thymidine incorporation in vitro.

Products are for research use only. Not for human use.