ARS-1323-alkyne


Catalog No. Size PriceQuantity
M28567-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

ARS-1323-alkyne, a switch-II pocket (S-IIP) inhibitor, is a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.

Product information

CAS Number: 2436544-27-1

Molecular Weight: 569.00

Formula: C28H27ClF2N6O3

Chemical Name: 3-{[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-[4-(prop-2-enoyl)piperazin-1-yl]quinazolin-2-yl]amino}-N-methyl-N-(prop-2-yn-1-yl)propanamide

Smiles: CN(CC#C)C(=O)CCNC1=NC2=C(C=C(Cl)C(C3=C(O)C=CC=C3F)=C2F)C(=N1)N1CCN(CC1)C(=O)C=C

InChiKey: FCCFZQSNDSLLMI-UHFFFAOYSA-N

InChi: InChI=1S/C28H27ClF2N6O3/c1-4-11-35(3)22(40)9-10-32-28-33-26-17(27(34-28)37-14-12-36(13-15-37)21(39)5-2)16-18(29)23(25(26)31)24-19(30)7-6-8-20(24)38/h1,5-8,16,38H,2,9-15H2,3H3,(H,32,33,34)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 35.71 mg/mL (62.76 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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