Description
POL1-IN-1 is a RNA polymerase 1 (POL1, also known as Pol I) inhibitor with an IC50 of less than 0.5 uM. POL1-IN-1 inhibits ribosome biogenesis by inhibiting POL1 transcription.
Product information
CAS Number: 1822358-25-7
Molecular Weight: 356.42
Formula: C21H20N6
Chemical Name: 4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-1,3,11-triazatetracyclo[8.7.0.0²,⁷.0¹²,¹⁷]heptadeca-2,4,6,8,10,12,14,16-octaene-9-carbonitrile
Smiles: C[C@@H]1CN(C[C@H](C)N1)C1=CC=C2C=C(C#N)C3=NC4=CC=CC=C4N3C2=N1
InChiKey: HFQPEPQECNSOFF-OKILXGFUSA-N
InChi: InChI=1S/C21H20N6/c1-13-11-26(12-14(2)23-13)19-8-7-15-9-16(10-22)21-24-17-5-3-4-6-18(17)27(21)20(15)25-19/h3-9,13-14,23H,11-12H2,1-2H3/t13-,14+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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