DC4SMe

DC4SMe, a phosphate prodrug of cytotoxic DNA alkylator DC4, can be used in the synthesis of Antibody-drug Conjugate (ADC). DC4SMe exhibits IC50s of 1.9 nM, 2.9 nM, and 1.8 nM for Ramos, Namalwa, and HL60/s cancer cells, respectively. DC4SMe can be used for the targeted treatment of cancer.

Product information

CAS Number: 615538-47-1

Molecular Weight: 764.21

Formula: C35H31ClN5O7PS2

Chemical Name: {[(1S)-1-(chloromethyl)-3-(5-{5-[3-(methyldisulfanyl)propanamido]-1H-indole-2-amido}-1H-indole-2-carbonyl)-1H,2H,3H-benzo[e]indol-5-yl]oxy}phosphonic acid

Smiles: CSSCCC(=O)NC1C=C2C=C(NC2=CC=1)C(=O)NC1C=C2C=C(NC2=CC=1)C(=O)N1C[C@@H](CCl)C2C1=CC(OP(O)(O)=O)=C1C=CC=CC1=2

InChiKey: GUHZUPDFYIAIMU-OAQYLSRUSA-N

InChi: InChI=1S/C35H31ClN5O7PS2/c1-50-51-11-10-32(42)37-22-6-8-26-19(12-22)14-28(39-26)34(43)38-23-7-9-27-20(13-23)15-29(40-27)35(44)41-18-21(17-36)33-25-5-3-2-4-24(25)31(16-30(33)41)48-49(45,46)47/h2-9,12-16,21,39-40H,10-11,17-18H2,1H3,(H,37,42)(H,38,43)(H2,45,46,47)/t21-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

The phosphate prodrug may be a suitable choice for ADCs of effector molecules that do not possess sufficient water solubility or stability.

Products are for research use only. Not for human use.