Description
SHP2-IN-6 is a potent SHP2 inhibitor, extracted from patent WO2017211303A1, compound 7, has an IC50 of 25.8 nM.
Product information
CAS Number: 2169223-48-5
Molecular Weight: 476.54
Formula: C22H26F2N6O2S
Chemical Name: 1-[4-({3-amino-5-[(4S)-4-amino-2-oxa-8-azaspiro[4.5]decan-8-yl]pyrazin-2-yl}sulfanyl)-3,3-difluoro-2,3-dihydro-1H-indol-1-yl]ethan-1-one
Smiles: CC(=O)N1CC(F)(F)C2=C(C=CC=C12)SC1=NC=C(N=C1N)N1CCC2(COC[C@H]2N)CC1
InChiKey: HGYTYZKWKUXRKA-MRXNPFEDSA-N
InChi: InChI=1S/C22H26F2N6O2S/c1-13(31)30-11-22(23,24)18-14(30)3-2-4-15(18)33-20-19(26)28-17(9-27-20)29-7-5-21(6-8-29)12-32-10-16(21)25/h2-4,9,16H,5-8,10-12,25H2,1H3,(H2,26,28)/t16-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
SHP2-IN-6 inhibits the proliferation of KYSE-520 cells with an IC50 of 2.17 μM.
Products are for research use only. Not for human use.
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