Description
GKI-1 is a Greatwall (GWL) kinase inhibitor with IC50s of 4.9 and 2.5 µM against hGWLFL and hGWL-KinDom, respectively. GKI-1 robustly inhibits ROCK1 with an IC50 of 11 µM, but only weakly affected PKA.
Product information
CAS Number: 2444764-03-6
Molecular Weight: 269.73
Formula: C15H12ClN3
Chemical Name: N-(4-chlorophenyl)-3-(1H-pyrazol-4-yl)aniline
Smiles: ClC1C=CC(=CC=1)NC1=CC(=CC=C1)C1=CNN=C1
InChiKey: GPXJDHFWTOJHQQ-UHFFFAOYSA-N
InChi: InChI=1S/C15H12ClN3/c16-13-4-6-14(7-5-13)19-15-3-1-2-11(8-15)12-9-17-18-10-12/h1-10,19H,(H,17,18)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 200 mg/mL (741.48 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
GKI-1 inhibits full-length human GWL, and shows cellular efficacy.
Products are for research use only. Not for human use.
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