Description
Coumetarol (Dicumoxane) is a vitamin K antagonist.
Product information
CAS Number: 4366-18-1
Molecular Weight: 380.35
Formula: C21H16O7
Chemical Name: 4-hydroxy-3-[1-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-methoxyethyl]-2H-chromen-2-one
Smiles: COCC(C1C(=O)OC2=CC=CC=C2C=1O)C1C(=O)OC2=CC=CC=C2C=1O
InChiKey: BUCJFFQZPGTGPX-UHFFFAOYSA-N
InChi: InChI=1S/C21H16O7/c1-26-10-13(16-18(22)11-6-2-4-8-14(11)27-20(16)24)17-19(23)12-7-3-5-9-15(12)28-21(17)25/h2-9,13,22-23H,10H2,1H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Coumetarol (Dicumoxane), an oral anticoagulant, is active in both models. The vitamin K antagonist Coumetarol is effective in both models after oral treatment but inhibits the thrombus formation more strongly in the arterio-venous shunt model. Treatment with the vitamin K antagonist Coumetarol in a dose of 25 mg/kg p.o. twice daily for 2 days results in a significant reduction in thrombus weight by 50% in the venous stasis model and by 75% in the arterio-venous shunt model. In both experiments the coagulation time as measured by the Thrombotest is prolonged to the same extent.
Products are for research use only. Not for human use.
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