Description
AZD1940 is an orally active, high affinity cannabinoid CB1/CB2 receptor agonist with pKi values of 7.93 and 9.06 for human CB1R and CB2R, respectively. AZD1940 shows a robust analgesia action.
Product information
CAS Number: 881413-29-2
Molecular Weight: 413.52
Formula: C20H29F2N3O2S
Chemical Name: N-{2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-1,3-benzodiazol-5-yl}ethane-1-sulfonamide
Smiles: CC(C)(C)C1=NC2=CC(=CC=C2N1CC1CCC(F)(F)CC1)NS(=O)(=O)CC
InChiKey: ZAGGGZCIFUQHOH-UHFFFAOYSA-N
InChi: InChI=1S/C20H29F2N3O2S/c1-5-28(26,27)24-15-6-7-17-16(12-15)23-18(19(2,3)4)25(17)13-14-8-10-20(21,22)11-9-14/h6-7,12,14,24H,5,8-11,13H2,1-4H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (241.83 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
AZD1940 binds with high affinity to human, rat and mouse CB1 and CB2 receptors and displays full agonism at both receptors in all three species.
In Vivo:
When given orally to rats, AZD1940 produces a robust analgesia in different models of inflammatory and neuropathic pain. For AZD1940, low brain uptake at analgesic doses has been demonstrated in both rats and primates.
Products are for research use only. Not for human use.
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