Description
SI-109 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36.
Product information
CAS Number: 2429877-30-3
Molecular Weight: 835.79
Formula: C40H44F2N7O9P
Chemical Name: [(2-{[(5S,8S,10aR)-3-acetyl-8-{[(1S)-3-carbamoyl-1-[(diphenylmethyl)carbamoyl]propyl]carbamoyl}-6-oxo-decahydropyrrolo[1,2-a][1,5]diazocin-5-yl]carbamoyl}-1H-indol-5-yl)difluoromethyl]phosphonic acid
Smiles: CC(=O)N1C[C@H](NC(=O)C2=CC3=CC(=CC=C3N2)C(F)(F)P(O)(O)=O)C(=O)N2[C@@H](CC[C@@H]2CC1)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(C1C=CC=CC=1)C1C=CC=CC=1
InChiKey: HBICZHLVBCLHSV-VUCLUUCHSA-N
InChi: InChI=1S/C40H44F2N7O9P/c1-23(50)48-19-18-28-13-16-33(38(54)45-30(15-17-34(43)51)36(52)47-35(24-8-4-2-5-9-24)25-10-6-3-7-11-25)49(28)39(55)32(22-48)46-37(53)31-21-26-20-27(12-14-29(26)44-31)40(41,42)59(56,57)58/h2-12,14,20-21,28,30,32-33,35,44H,13,15-19,22H2,1H3,(H2,43,51)(H,45,54)(H,46,53)(H,47,52)(H2,56,57,58)/t28-,30+,32+,33+/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 150 mg/mL (179.47 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
SI-109 exerts a moderate growth inhibitory activity in MOLM-16 cells (IC50=3 μM). SI-109 is ineffective in inhibition of STAT3 Y705 phosphorylation and in suppression of c-Myc expression at concentrations as high as 10 μM.
Products are for research use only. Not for human use.
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