Diphyllin


Catalog No. Size PriceQuantity
M29016-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Diphyllin is an arylnaphthalene lignan isolated from Justicia procumbens and is a potent HIV-1 inhibitor with an IC50 of 0.38 μM. Diphyllin is active against vesicular stomatitis virus (VSV) and influenza virus. Diphyllin is a vacuolar type H+-ATPase (V-ATPase) inhibitor with an IC50 value of 17 nM and inhibits lysosomal acidification in human osteoclasts. Diphyllin inhibits NO production with an IC50 of 50 μM and has anticancer and anti-inflammatory activities.

Product information

CAS Number: 22055-22-7

Molecular Weight: 380.35

Formula: C21H16O7

Chemical Name: 9-(2H-1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-1H,3H-naphtho[2,3-c]furan-1-one

Smiles: COC1=CC2=C(O)C3COC(=O)C=3C(=C2C=C1OC)C1C=C2OCOC2=CC=1

InChiKey: VMEJANRODATDOF-UHFFFAOYSA-N

InChi: InChI=1S/C21H16O7/c1-24-15-6-11-12(7-16(15)25-2)20(22)13-8-26-21(23)19(13)18(11)10-3-4-14-17(5-10)28-9-27-14/h3-7,22H,8-9H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 14.29 mg/mL (37.57 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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