Description
KPT-6566, a potent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC50 of 640 nM and a Ki of 625.2 nM for PIN1 PPIase domain. Anti-cancer activity.
Product information
CAS Number: 881487-77-0
Molecular Weight: 443.54
Formula: C22H21NO5S2
Chemical Name: 2-({4-[(4-tert-butylbenzenesulfonyl)imino]-1-oxo-1,4-dihydronaphthalen-2-yl}sulfanyl)acetic acid
Smiles: CC(C)(C)C1C=CC(=CC=1)S(=O)(=O)N=C1C=C(SCC(O)=O)C(=O)C2=CC=CC=C12
InChiKey: BXWWOKYIKNEEHJ-PTGBLXJZSA-N
InChi: InChI=1S/C22H21NO5S2/c1-22(2,3)14-8-10-15(11-9-14)30(27,28)23-18-12-19(29-13-20(24)25)21(26)17-7-5-4-6-16(17)18/h4-12H,13H2,1-3H3,(H,24,25)/b23-18+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 19.23 mg/mL (43.36 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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