Aminooxy-PEG2-alcohol


Catalog No. Size PriceQuantity
M29162-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Aminooxy-PEG2-alcohol is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Aminooxy-PEG2-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 185022-12-2

Molecular Weight: 121.14

Formula: C4H11NO3

Chemical Name: 2-[2-(aminooxy)ethoxy]ethan-1-ol

Smiles: NOCCOCCO

InChiKey: CMECGOAFIHUPBI-UHFFFAOYSA-N

InChi: InChI=1S/C4H11NO3/c5-8-4-3-7-2-1-6/h6H,1-5H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.

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