EGFR-IN-9


Catalog No. Size PriceQuantity
M29553-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

EGFR-IN-9 (Compound 8) is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M). EGFR-IN-9 has antitumor activity.

Product information

CAS Number: 1226549-39-8

Molecular Weight: 476.53

Formula: C29H24N4O3

Chemical Name: N-[3-(4-{[(1S)-2-hydroxy-1-phenylethyl]amino}-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl]prop-2-enamide

Smiles: C=CC(=O)NC1=CC(=CC=C1)C1=C(OC2N=CN=C(N[C@H](CO)C3C=CC=CC=3)C1=2)C1C=CC=CC=1

InChiKey: GFTOODFOXIDLNF-HSZRJFAPSA-N

InChi: InChI=1S/C29H24N4O3/c1-2-24(35)32-22-15-9-14-21(16-22)25-26-28(33-23(17-34)19-10-5-3-6-11-19)30-18-31-29(26)36-27(25)20-12-7-4-8-13-20/h2-16,18,23,34H,1,17H2,(H,32,35)(H,30,31,33)/t23-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

EGFR-IN-9 (Compound 8) shows antiproliferative activity in HCC827 lung cancer cell line with an IC50 of 8 nM.

Products are for research use only. Not for human use.

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