4, 4'-Dimethoxybenzil


Catalog No. Size PriceQuantity
M29593-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

4,4'-Dimethoxybenzil is a human intestinal carboxyl esterase (hiCE) inhibitor with Ki of 70 nM.

Product information

CAS Number: 1226-42-2

Molecular Weight: 270.28

Formula: C16H14O4

Chemical Name: bis(4-methoxyphenyl)ethane-1,2-dione

Smiles: COC1C=CC(=CC=1)C(=O)C(=O)C1C=CC(=CC=1)OC

InChiKey: YNANGXWUZWWFKX-UHFFFAOYSA-N

InChi: InChI=1S/C16H14O4/c1-19-13-7-3-11(4-8-13)15(17)16(18)12-5-9-14(20-2)10-6-12/h3-10H,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 50 mg/mL (184.99 mM; Need ultrasonic). H2O : < 0.1 mg/mL (insoluble).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

By reducing irinotecaninduced diarrhea, hiCE inhibitors (e.g., 4,4'-Dimethoxybenzil, Compound 8) can improve the anti-cancer efficacy of irinotecan. To find effective hiCE inhibitors, a new virtual screening protocol that combines pharmacophore models derived from the hiCE structure and its ligands has been proposed.

Products are for research use only. Not for human use.

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