Description
Clozic is a potential anti-arthritic agent.
Product information
CAS Number: 22494-47-9
Molecular Weight: 304.77
Formula: C17H17ClO3
Chemical Name: 2-({4'-chloro-[1,1'-biphenyl]-4-yl}methoxy)-2-methylpropanoic acid
Smiles: CC(C)(OCC1C=CC(=CC=1)C1C=CC(Cl)=CC=1)C(O)=O
InChiKey: UGOFYAXVVVXMQT-UHFFFAOYSA-N
InChi: InChI=1S/C17H17ClO3/c1-17(2,16(19)20)21-11-12-3-5-13(6-4-12)14-7-9-15(18)10-8-14/h3-10H,11H2,1-2H3,(H,19,20)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Clozic is a potential anti-arthritic agent. Concentrations of Clozic greater than 50 μM cause a dose-dependent decrease in the amount of matrix protein synthesized by RHMC cell cultures. Inhibition of RHMC cell culture growth by Clozic occurs in a dose-dependent manner. The anti-proliferative effect of Clozic on RHMC cell growth is reversible. Lactate dehydrogenase (LDH) levels in media taken from RHMC cell cultures exposed to 500 μM Clozic for 3 days do not significantly differ from LDH levels in control cell culture media.
Products are for research use only. Not for human use.
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