Description
CMF019 is a potent and small molecule agonist at Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ with pKi values of 8.58, 8.49 and 8.71 for human, rat, and mouse, respectively. CMF019 mimics the beneficial cardiovascular actions of apelin in rodents. Apelin receptor (APJ) is a G protein-coupled receptor (GPCR) activated by the endogenous peptide apelin.
Product information
CAS Number: 1586787-08-7
Molecular Weight: 455.61
Formula: C25H33N3O3S
Chemical Name: (3S)-5-methyl-3-{[1-(pentan-3-yl)-2-[(thiophen-2-yl)methyl]-1H-1,3-benzodiazol-5-yl]formamido}hexanoic acid
Smiles: CC(C)C[C@@H](CC(O)=O)NC(=O)C1=CC=C2C(=C1)N=C(CC1=CC=CS1)N2C(CC)CC
InChiKey: VCQKKZXFASLXAH-SFHVURJKSA-N
InChi: InChI=1S/C25H33N3O3S/c1-5-19(6-2)28-22-10-9-17(25(31)26-18(12-16(3)4)14-24(29)30)13-21(22)27-23(28)15-20-8-7-11-32-20/h7-11,13,16,18-19H,5-6,12,14-15H2,1-4H3,(H,26,31)(H,29,30)/t18-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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