JTE-952


Catalog No. Size PriceQuantity
M29980-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

JTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis.

Product information

CAS Number: 1255303-54-8

Molecular Weight: 518.60

Formula: C30H34N2O6

Chemical Name: (2S)-3-{[2-(3-{4-[(4-cyclopropylphenyl)methoxy]-3-methoxyphenyl}azetidine-1-carbonyl)pyridin-4-yl]methoxy}propane-1,2-diol

Smiles: COC1=CC(=CC=C1OCC1=CC=C(C=C1)C1CC1)C1CN(C1)C(=O)C1=CC(COC[C@@H](O)CO)=CC=N1

InChiKey: LTTJGQBDGMNWHJ-SANMLTNESA-N

InChi: InChI=1S/C30H34N2O6/c1-36-29-13-24(8-9-28(29)38-18-20-2-4-22(5-3-20)23-6-7-23)25-14-32(15-25)30(35)27-12-21(10-11-31-27)17-37-19-26(34)16-33/h2-5,8-13,23,25-26,33-34H,6-7,14-19H2,1H3/t26-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

JTE-952 (3 mg/kg, p.o. once-daily) treatment reduces the overall progression of the clinical score, including inflammation and bone erosion in mouse model of collagen-induced arthritis (CIA model).

Products are for research use only. Not for human use.

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