Ambroxol


Catalog No. Size PriceQuantity
M29997-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Ambroxol (NA-872), an active metabolite of the prodrug Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.

Product information

CAS Number: 18683-91-5

Molecular Weight: 378.10

Formula: C13H18Br2N2O

Chemical Name: 4-{[(2-amino-3,5-dibromophenyl)methyl]amino}cyclohexan-1-ol

Smiles: NC1C(Br)=CC(Br)=CC=1CNC1CCC(O)CC1

InChiKey: JBDGDEWWOUBZPM-UHFFFAOYSA-N

InChi: InChI=1S/C13H18Br2N2O/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10/h5-6,10-11,17-18H,1-4,7,16H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 200 mg/mL (528.96 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Ambroxol (NA-872; 1, 3, 4, 5 mM for 12 consecutive days in drinking water) results in increased brain glucocerebrosidase activity in wild-type mice, transgenic mice expressing the heterozygous L444P mutation in the murine glucocerebrosidase 1 gene, and transgenic mice overexpressing human α-synuclein.

Products are for research use only. Not for human use.

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