Description
Lanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects.
Product information
CAS Number: 153322-06-6
Molecular Weight: 271.19
Formula: C13H16Cl2N2
Chemical Name: (1S)-1-phenyl-2-(pyridin-2-yl)ethan-1-amine dihydrochloride
Smiles: Cl.Cl.N[C@@H](CC1=CC=CC=N1)C1C=CC=CC=1
InChiKey: KHJHFYAGQZYCLC-GXKRWWSZSA-N
InChi: InChI=1S/C13H14N2.2ClH/c14-13(11-6-2-1-3-7-11)10-12-8-4-5-9-15-12;;/h1-9,13H,10,14H2;2*1H/t13-;;/m0../s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 240 mg/mL (884.99 mM; Need ultrasonic). H2O : ≥ 100 mg/mL (368.75 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects.Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine.
Products are for research use only. Not for human use.
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