LEI-101


Catalog No. Size PriceQuantity
M30032-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

LEI-101 is a potent, selective, and orally bioavailable cannabinoid CB2 receptor agonist, with a pEC50 of 8 for hCB2, and a pKi of less than 4 for hERG. LEI-101 is ~100-fold more potent in binding to CB2 receptors than to CB1 receptors.

Product information

CAS Number: 2250025-91-1

Molecular Weight: 508.99

Formula: C23H26ClFN4O4S

Chemical Name: 4-[(6-{4-[(3-cyclopropyl-2,4-dioxoimidazolidin-1-yl)methyl]phenyl}-3-fluoropyridin-2-yl)methyl]-1λ⁶-thiomorpholine-1,1-dione hydrochloride

Smiles: Cl.O=S1(=O)CCN(CC2=NC(=CC=C2F)C2=CC=C(CN3CC(=O)N(C4CC4)C3=O)C=C2)CC1

InChiKey: APLLNJWPLUIBCG-UHFFFAOYSA-N

InChi: InChI=1S/C23H25FN4O4S.ClH/c24-19-7-8-20(25-21(19)14-26-9-11-33(31,32)12-10-26)17-3-1-16(2-4-17)13-27-15-22(29)28(23(27)30)18-5-6-18;/h1-4,7-8,18H,5-6,9-15H2;1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

LEI-101 (2, 6, and 20 mg/kg, po) shows in vivo activity in a spinal nerve ligation model of neuropathic pain in rats. LEI‐101 (p.o. or i.p.) at 3 or 10 mg/kg dose-dependently prevents kidney dysfunction and/or morphological damage induced by cisplatin in mice.

Products are for research use only. Not for human use.

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