Description
CHK1-IN-4 (Compound 3) is a potent checkpoint kinase 1 (chk1) inhibitor, and potently inhibits chk1 phosphorylation in the tumor cells. CHK1-IN-4 has anti-tumor activity.
Product information
CAS Number: 2120398-41-4
Molecular Weight: 444.29
Formula: C18H18BrN7O2
Chemical Name: 5-({5-[2-(3-aminopropoxy)-4-bromo-6-methoxyphenyl]-1H-pyrazol-3-yl}amino)pyrazine-2-carbonitrile
Smiles: COC1=CC(Br)=CC(OCCCN)=C1C1=CC(NC2=CN=C(C=N2)C#N)=NN1
InChiKey: LWOYEDQROLTYBT-UHFFFAOYSA-N
InChi: InChI=1S/C18H18BrN7O2/c1-27-14-5-11(19)6-15(28-4-2-3-20)18(14)13-7-16(26-25-13)24-17-10-22-12(8-21)9-23-17/h5-7,9-10H,2-4,20H2,1H3,(H2,23,24,25,26)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
CHK1-IN-4 (Compound 3) (40 mg/kg, IV, twice a week) alone enhances anti-tumor growth activity of CPT1 in the tumor model.
Products are for research use only. Not for human use.
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