Nav1.7-IN-3


Catalog No. Size PriceQuantity
M30067-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration.

Product information

CAS Number: 1788872-06-9

Molecular Weight: 430.95

Formula: C17H20ClFN4O2S2

Chemical Name: 5-chloro-2-fluoro-4-{[(hexahydro-1H-pyrrolizin-7a-yl)methyl]amino}-N-(1,3-thiazol-2-yl)benzene-1-sulfonamide

Smiles: O=S(=O)(NC1=NC=CS1)C1=CC(Cl)=C(C=C1F)NCC12CCCN1CCC2

InChiKey: XFWKBJBSEOZBRA-UHFFFAOYSA-N

InChi: InChI=1S/C17H20ClFN4O2S2/c18-12-9-15(27(24,25)22-16-20-5-8-26-16)13(19)10-14(12)21-11-17-3-1-6-23(17)7-2-4-17/h5,8-10,21H,1-4,6-7,11H2,(H,20,22)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Nav1.7-IN-3 (compound 5) shows excellent potency, selectivity, behavioral efficacy in a rodent pain model (30 mg/kg, oral, 35 minutes), and efficacy in a mouse itch model (30 mg/kg, oral, 30 minutes).

Products are for research use only. Not for human use.

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