Description
RORγt agonist 1 (compound 14) is a potent, orally bioavailable RORγt agonist with an EC50 of 20.8 nM. RORγt agonist 1 showes high metabolic stability, improved aqueous solubility and excellent mouse PK profile. RORγt agonist 1 is a potential candidate of RORγt agonist for cancer immunotherapy.
Product information
CAS Number: 2377378-89-5
Molecular Weight: 545.45
Formula: C24H17F6NO5S
Chemical Name: 2-{6-[3-(difluoromethoxy)-5-fluorophenyl]-1-[3-(trifluoromethyl)benzenesulfonyl]-2,3-dihydro-1H-indol-2-yl}acetic acid
Smiles: OC(=O)CC1CC2=CC=C(C=C2N1S(=O)(=O)C1=CC(=CC=C1)C(F)(F)F)C1=CC(F)=CC(=C1)OC(F)F
InChiKey: UAFXMLYFRFORFY-UHFFFAOYSA-N
InChi: InChI=1S/C24H17F6NO5S/c25-17-6-15(8-19(11-17)36-23(26)27)13-4-5-14-7-18(12-22(32)33)31(21(14)9-13)37(34,35)20-3-1-2-16(10-20)24(28,29)30/h1-6,8-11,18,23H,7,12H2,(H,32,33)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
RORγt agonist 1 shows high metabolic stability (t1/2 = 113 min) in mouse liver microsome and has improved aqueous solubility at pH 7.4.
Products are for research use only. Not for human use.
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