Description
CP-601927 is a selective α4β2 nicotinic acetylcholine receptor (nAChR) partial agonist (Ki=1.2 nM; EC50=2.6 μM). CP-601927 shows good brain penetration and antidepressant-like properties.
Product information
CAS Number: 357425-02-6
Molecular Weight: 227.23
Formula: C12H12F3N
Chemical Name: (1S,8R)-4-(trifluoromethyl)-10-azatricyclo[6.3.1.0²,⁷]dodeca-2(7),3,5-triene
Smiles: FC(F)(F)C1=CC2[C@@H]3C[C@@H](CNC3)C=2C=C1
InChiKey: RNOBTWYQAWEZHH-JGVFFNPUSA-N
InChi: InChI=1S/C12H12F3N/c13-12(14,15)9-1-2-10-7-3-8(6-16-5-7)11(10)4-9/h1-2,4,7-8,16H,3,5-6H2/t7-,8+/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
CP-601927 (0.125 mg/kg-1.5 mg/kg; i.p.; C57BL/6J male mice) has antidepressant-like activity in animal models.
Products are for research use only. Not for human use.
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