Description
Fosphenytoin sodium is a phenytoin prodrug with similar anticonvulsant properties.
Product information
CAS Number: 92134-98-0
Molecular Weight: 406.24
Formula: C16H13N2Na2O6P
Chemical Name: disodium (2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl phosphate
Smiles: [Na+].[Na+].[O-]P([O-])(=O)OCN1C(=O)NC(C2C=CC=CC=2)(C2C=CC=CC=2)C1=O
InChiKey: GQPXYJNXTAFDLT-UHFFFAOYSA-L
InChi: InChI=1S/C16H15N2O6P.2Na/c19-14-16(12-7-3-1-4-8-12,13-9-5-2-6-10-13)17-15(20)18(14)11-24-25(21,22)23;;/h1-10H,11H2,(H,17,20)(H2,21,22,23);;/q;2*+1/p-2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: H2O : ≥ 100 mg/mL (246.16 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
Fosphenytoin is an effective neuroprotectant against ischemia-induced damage. In fosphenytoin (30 mg/kg, i.m.)-treated rat 5 min after ischemia episode, hippocampal CA1 pyramidal neurons remain at near control level (13.90 +/- 0.92), however, GFAP staining iss not significantly changed. In fosphenytoin (84 mg/kg)-treated rat, the relative bioavailability of fosphenytoin is 83%. In fully kindled female Wistar rats, fosphenytoin dose-dependently increases the focal seizure (afterdischarge) threshold. Seizure severity and duration at threshold are reduced only after the highest does of fosphenytoin tested (84 mg/kg).
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.