Description
SPR720 (pVXc-486) is an orally active and potent phosphate prodrug of SPR719 (VXc-486; HY-12930). SPR720 has potent bactericidal activities in vivo.
Product information
CAS Number: 1384984-31-9
Molecular Weight: 508.44
Formula: C21H26FN6O6P
Chemical Name: {[2-(5-{2-[(ethylcarbamoyl)amino]-5-fluoro-4-[(2R)-oxolan-2-yl]-1H-1,3-benzodiazol-6-yl}pyrimidin-2-yl)propan-2-yl]oxy}phosphonic acid
Smiles: CCNC(=O)NC1NC2=CC(C3C=NC(=NC=3)C(C)(C)OP(O)(O)=O)=C(F)C([C@H]3CCCO3)=C2N=1
InChiKey: COTQDURISRILOR-CQSZACIVSA-N
InChi: InChI=1S/C21H26FN6O6P/c1-4-23-20(29)28-19-26-13-8-12(16(22)15(17(13)27-19)14-6-5-7-33-14)11-9-24-18(25-10-11)21(2,3)34-35(30,31)32/h8-10,14H,4-7H2,1-3H3,(H2,30,31,32)(H3,23,26,27,28,29)/t14-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
SPR720 (pVXc-486; oral gavage; 10, 30, 100 mg/kg; once per day; 5 times per week for 4 weeks) reduces the mycobacterial burden in a model of chronic tuberculosis infection in mice. SPR720 (oral; 100 mg/kg; once per day; 5 days per week, for 8 weeks) improves the bactericidal activities of antimycobacterial drugs.
Products are for research use only. Not for human use.
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