Description
Glucokinase activator 1 is a liver-directed glucokinase activator with an EC50 of 34 nM.
Product information
CAS Number: 1328987-85-4
Molecular Weight: 586.58
Formula: C27H20F2N2O7S2
Chemical Name: 4-({2-[(2R)-2-[4-(cyclopropanesulfonyl)phenyl]-2-(2,4-difluorophenoxy)acetamido]-1,3-thiazol-5-yl}oxy)benzoic acid
Smiles: OC(=O)C1C=CC(=CC=1)OC1=CN=C(NC(=O)[C@H](OC2=CC=C(F)C=C2F)C2C=CC(=CC=2)S(=O)(=O)C2CC2)S1
InChiKey: XJFUEUNGZVAEIX-XMMPIXPASA-N
InChi: InChI=1S/C27H20F2N2O7S2/c28-17-5-12-22(21(29)13-17)38-24(15-3-8-19(9-4-15)40(35,36)20-10-11-20)25(32)31-27-30-14-23(39-27)37-18-6-1-16(2-7-18)26(33)34/h1-9,12-14,20,24H,10-11H2,(H,33,34)(H,30,31,32)/t24-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
Glucokinase activator 1 (3 to 300 mg/kg, oral, 180 minutes) shows a dose dependent improvement in glucose excursion in oGTT in a DIO mouse model of T2D. The predominant liver-directed tissue distribution of Glucokinase activator 1 ensures a good safety window with respect to hypoglycemia over a 10-fold dose range.
Products are for research use only. Not for human use.
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