Glucokinase activator 1


Catalog No. Size PriceQuantity
M30206-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Glucokinase activator 1 is a liver-directed glucokinase activator with an EC50 of 34 nM.

Product information

CAS Number: 1328987-85-4

Molecular Weight: 586.58

Formula: C27H20F2N2O7S2

Chemical Name: 4-({2-[(2R)-2-[4-(cyclopropanesulfonyl)phenyl]-2-(2,4-difluorophenoxy)acetamido]-1,3-thiazol-5-yl}oxy)benzoic acid

Smiles: OC(=O)C1C=CC(=CC=1)OC1=CN=C(NC(=O)[C@H](OC2=CC=C(F)C=C2F)C2C=CC(=CC=2)S(=O)(=O)C2CC2)S1

InChiKey: XJFUEUNGZVAEIX-XMMPIXPASA-N

InChi: InChI=1S/C27H20F2N2O7S2/c28-17-5-12-22(21(29)13-17)38-24(15-3-8-19(9-4-15)40(35,36)20-10-11-20)25(32)31-27-30-14-23(39-27)37-18-6-1-16(2-7-18)26(33)34/h1-9,12-14,20,24H,10-11H2,(H,33,34)(H,30,31,32)/t24-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Glucokinase activator 1 (3 to 300 mg/kg, oral, 180 minutes) shows a dose dependent improvement in glucose excursion in oGTT in a DIO mouse model of T2D. The predominant liver-directed tissue distribution of Glucokinase activator 1 ensures a good safety window with respect to hypoglycemia over a 10-fold dose range.

Products are for research use only. Not for human use.

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