JMS-17-2


Catalog No. Size PriceQuantity
M30207-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 impairs metastatic seeding and colonization of breast cancer cells.

Product information

CAS Number: 1380392-05-1

Molecular Weight: 419.95

Formula: C25H26ClN3O

Chemical Name: 5-{3-[4-(4-chlorophenyl)piperidin-1-yl]propyl}-4H,5H-pyrrolo[1,2-a]quinoxalin-4-one

Smiles: O=C1C2=CC=CN2C2=CC=CC=C2N1CCCN1CCC(CC1)C1C=CC(Cl)=CC=1

InChiKey: WOSMCMULWWHMIV-UHFFFAOYSA-N

InChi: InChI=1S/C25H26ClN3O/c26-21-10-8-19(9-11-21)20-12-17-27(18-13-20)14-4-16-29-23-6-2-1-5-22(23)28-15-3-7-24(28)25(29)30/h1-3,5-11,15,20H,4,12-14,16-18H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 25 mg/mL (59.53 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

JMS-17-2 (10 mg/kg; aministered i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice.

Products are for research use only. Not for human use.

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