Description
Polaprezinc is an orally bioavailable chelate composed of zinc and L-carnosine, with potential gastroprotective, anti-oxidant, anti-ulcer and anti-inflammatory activities.
Product information
CAS Number: 107667-60-7
Molecular Weight: 290.63
Formula: C9H13N4O3Zn
Chemical Name: (3-aminopropanoyl)[(1S)-1-carboxy-2-(1H-imidazol-5-yl)ethyl]azanide zinc
Smiles: [Zn].NCCC(=O)[N-][C@@H](CC1=CN=CN1)C(O)=O
InChiKey: GFWBKUDRXMQSFD-FJXQXJEOSA-M
InChi: InChI=1S/C9H14N4O3.Zn/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6;/h4-5,7H,1-3,10H2,(H3,11,12,13,14,15,16);/p-1/t7-;/m0./s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : < 1 mg/mL (insoluble or slightly soluble). H2O : 3.37 mg/mL (11.68 mM; ultrasonic and warming and adjust pH to 1-2 with HCl).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
Polaprezinc (PZ) is an antiulcer drug and a chelating compound consisting of a zinc ion, L-carnosine, a β-alanine dipeptide and L-histidine. Polaprezinc exerts antioxidant effects and scavenges free radicals. The efficacy of Polaprezinc is reported for acute radiation proctitis in an animal model and demonstrates that Polaprezinc has an anti-inflammatory effect following exposure to radiation.
Products are for research use only. Not for human use.
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