1-Acetyl-3-o-toluyl-5-fluorouracil


Catalog No. Size PriceQuantity
M30243-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

1-Acetyl-3-o-toluyl-5-fluorouracil is a potent an antineoplastic agent.

Product information

CAS Number: 71861-76-2

Molecular Weight: 290.25

Formula: C14H11FN2O4

Chemical Name: 1-acetyl-5-fluoro-3-(2-methylbenzoyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione

Smiles: CC(=O)N1C=C(F)C(=O)N(C(=O)C2=CC=CC=C2C)C1=O

InChiKey: DRXHAKVGNKHFMB-UHFFFAOYSA-N

InChi: InChI=1S/C14H11FN2O4/c1-8-5-3-4-6-10(8)12(19)17-13(20)11(15)7-16(9(2)18)14(17)21/h3-7H,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil demonstrates a remarkable effect on MH134 solid tumors, the effect being more marked than that of subcutaneous administration of 1-Acetyl-3-o-toluyl-5-fluorouracil. Anti-tumor activity of oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at a dose of 0.2 mmol/kg/d is comparable to that of subcutaneous administration of 5-fluorouracil at the same dose. The level of decrease in thymus weight and the magnitude of increase of spleen weight following oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at any dose are smaller than those by subcutaneous administration of 5-fluorouracil (0.2 mmol/kg/d).

Products are for research use only. Not for human use.

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