hDHODH-IN-5


Catalog No. Size PriceQuantity
M30343-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

DHODH-IN-7 is a human dihydroorotate dehydrogenase (DHODH) inhibitor, with an IC50 of 0.91 μM. DHODH-IN-7 induces differentiation in acute myeloid leukemia.

Product information

CAS Number: 2029049-77-0

Molecular Weight: 390.40

Formula: C21H21F3N2O2

Chemical Name: N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-3-{[4-(trifluoromethyl)phenyl]formamido}propanamide

Smiles: O=C(CCNC(=O)C1C=CC(=CC=1)C(F)(F)F)N[C@@H]1CCCC2=CC=CC=C21

InChiKey: PBJCCXHBDNQZSF-GOSISDBHSA-N

InChi: InChI=1S/C21H21F3N2O2/c22-21(23,24)16-10-8-15(9-11-16)20(28)25-13-12-19(27)26-18-7-3-5-14-4-1-2-6-17(14)18/h1-2,4,6,8-11,18H,3,5,7,12-13H2,(H,25,28)(H,26,27)/t18-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

The lysozyme-GFPER-HoxA9 murine cell line (ER-HOX-GFP) and the THP1 and U937 human AML cell lines were cultured with compounds in a 4-day differentiation assay. DHODH-IN-7 shows EC50s of 3.6, 2.7, and 2.5 μM for ER-HOX-GFP, THP1 and U937 human AML cell lines, respectively.

Products are for research use only. Not for human use.

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