Epoxylathyrol


Catalog No. Size PriceQuantity
M30647-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Epoxylathyrol, an epoxylathyrane derivative isolated from the Euphorbia boetica, is a P-glycoprotein (P-gp) inhibitor. Epoxylathyrol is a P-gp-mediated multidrug resistance (MDR) reverser.

Product information

CAS Number: 28649-60-7

Molecular Weight: 350.45

Formula: C20H30O5

Chemical Name: (1'R,2R,5'R,7'S,11'S,12'R,13'S,14'S)-1',11',13'-trihydroxy-3',6',6',14'-tetramethylspiro[oxirane-2,10'-tricyclo[10.3.0.0⁵,⁷]pentadecan]-3'-en-2'-one

Smiles: CC1(C)[C@@H]2C=C(C)C(=O)[C@@]3(O)C[C@H](C)[C@H](O)[C@@H]3[C@H](O)[C@]3(CO3)CC[C@H]12 |t:4|

InChiKey: VEFQDSXSELSHMX-HMZDNQSVSA-N

InChi: InChI=1S/C20H30O5/c1-10-7-13-12(18(13,3)4)5-6-19(9-25-19)17(23)14-15(21)11(2)8-20(14,24)16(10)22/h7,11-15,17,21,23-24H,5-6,8-9H2,1-4H3/b10-7-/t11-,12-,13+,14+,15-,17-,19+,20+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Epoxylathyrol has no significant antiproliferative activity in EPG85-257P (parental; IC50>100 uM), EPG85-257RNOV (multidrug resistance [MDR] phenotype; IC50>100 uM), and EPG85-257RDB (multidrug resistance [MDR] phenotype; IC50=70.53 uM).

Products are for research use only. Not for human use.

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