eIF4A3-IN-1


Catalog No. Size PriceQuantity
M30766-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD.

Product information

CAS Number: 2095486-67-0

Molecular Weight: 588.88

Formula: C29H23BrClN5O2

Chemical Name: 3-{4-[(3S)-4-(4-bromobenzoyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-5-methyl-1H-pyrazol-1-yl}benzonitrile

Smiles: CC1=C(C=NN1C1=CC(=CC=C1)C#N)C(=O)N1C[C@H](C2C=CC(Cl)=CC=2)N(CC1)C(=O)C1C=CC(Br)=CC=1

InChiKey: BDGKKHWJYBQRIE-HHHXNRCGSA-N

InChi: InChI=1S/C29H23BrClN5O2/c1-19-26(17-33-36(19)25-4-2-3-20(15-25)16-32)29(38)34-13-14-35(28(37)22-5-9-23(30)10-6-22)27(18-34)21-7-11-24(31)12-8-21/h2-12,15,17,27H,13-14,18H2,1H3/t27-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 200 mg/mL (339.63 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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