BACE1-IN-4


Catalog No. Size PriceQuantity
M30810-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

BACE1-IN-4 is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective at BACE1 over BACE2. Anti-Alzheimer’s disease.

Product information

CAS Number: 2361157-92-6

Molecular Weight: 511.57

Formula: C21H23F2N5O4S2

Chemical Name: N-{3-[(5R)-3-amino-5-methyl-9,9-dioxo-2,9λ⁶-dithia-4-azaspiro[5.5]undec-3-en-5-yl]-4-fluorophenyl}-5-(fluoromethoxy)pyrazine-2-carboxamide

Smiles: C[C@@]1(N=C(N)SCC21CCS(=O)(=O)CC2)C1=CC(=CC=C1F)NC(=O)C1=CN=C(C=N1)OCF

InChiKey: DZTJZUAOGBUBNK-HXUWFJFHSA-N

InChi: InChI=1S/C21H23F2N5O4S2/c1-20(21(11-33-19(24)28-20)4-6-34(30,31)7-5-21)14-8-13(2-3-15(14)23)27-18(29)16-9-26-17(10-25-16)32-12-22/h2-3,8-10H,4-7,11-12H2,1H3,(H2,24,28)(H,27,29)/t20-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

BACE1-IN-4 (Compound 22) is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective at BACE1 over BACE2 (IC50, 2090 nM; Ki, 1740 nM).

Products are for research use only. Not for human use.

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