CDK9-IN-9


Catalog No. Size PriceQuantity
M30830-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

CDK9-IN-9 (example 2) is a potent and selective CDK9 inhibitor with an IC50 of 1.8 nM. CDK9-IN-9 inhibits CDK2 with an IC50 of 155 nM. CDK9-IN-9 has anti-cancer activity.

Product information

CAS Number: 2246956-84-1

Molecular Weight: 459.51

Formula: C22H23F2N5O2S

Chemical Name: ({3,20-difluoro-13-oxa-5,7,18,25-tetraazatetracyclo[17.3.1.1²,⁶.1⁸,¹²]pentacosa-1(23),2,4,6(25),8,10,12(24),19,21-nonaen-10-yl}methyl)(imino)methyl-λ⁶-sulfanone

Smiles: CS(=N)(=O)CC1C=C2C=C(C=1)OCCCCNC1C=C(C=CC=1F)C1N=C(N2)N=CC=1F

InChiKey: PNHBMABVSBQFDU-UHFFFAOYSA-N

InChi: InChI=1S/C22H23F2N5O2S/c1-32(25,30)13-14-8-16-11-17(9-14)31-7-3-2-6-26-20-10-15(4-5-18(20)23)21-19(24)12-27-22(28-16)29-21/h4-5,8-12,25-26H,2-3,6-7,13H2,1H3,(H,27,28,29)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CDK9-IN-9 (example 2) inhibits the proliferation of HeLa, HeLa-MaTu-ADR, NCI-H460, DU145, Caco-2, B16F10, A2780 and MOLM-13 cells with IC50s of 4.4 nM, 5.3 nM, 9.2 nM, 4.5 nM, 8.4 nM, 1.2 nM, 1.2 nM, 2.0 nM, respectively.

Products are for research use only. Not for human use.

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