Description
Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor. Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM.
Product information
CAS Number: 1644060-37-6
Molecular Weight: 446.54
Formula: C27H30N2O4
Chemical Name: ethyl (3S,3aR)-1-({[1,1'-biphenyl]-4-yl}methyl)-3-[(methylcarbamoyl)methyl]-2-oxo-2,3,3a,4,5,6-hexahydro-1H-indole-3a-carboxylate
Smiles: CCOC(=O)[C@@]12CCCC=C1N(CC1C=CC(=CC=1)C1C=CC=CC=1)C(=O)[C@H]2CC(=O)NC
InChiKey: VFGLXHHVYNTCPD-AJTFRIOCSA-N
InChi: InChI=1S/C27H30N2O4/c1-3-33-26(32)27-16-8-7-11-23(27)29(25(31)22(27)17-24(30)28-2)18-19-12-14-21(15-13-19)20-9-5-4-6-10-20/h4-6,9-15,22H,3,7-8,16-18H2,1-2H3,(H,28,30)/t22-,27-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 50 mg/mL (111.97 mM; Need ultrasonic). H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Fumarate hydratase-IN-1 inhibits SW620, ACHN, HCT-116, PC3, and SK-MEL-28 cell lines with a mean IC50 of 2.2 μM.
Products are for research use only. Not for human use.
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