Fumarate hydratase-IN-1


Catalog No. Size PriceQuantity
M30879-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor. Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM.

Product information

CAS Number: 1644060-37-6

Molecular Weight: 446.54

Formula: C27H30N2O4

Chemical Name: ethyl (3S,3aR)-1-({[1,1'-biphenyl]-4-yl}methyl)-3-[(methylcarbamoyl)methyl]-2-oxo-2,3,3a,4,5,6-hexahydro-1H-indole-3a-carboxylate

Smiles: CCOC(=O)[C@@]12CCCC=C1N(CC1C=CC(=CC=1)C1C=CC=CC=1)C(=O)[C@H]2CC(=O)NC

InChiKey: VFGLXHHVYNTCPD-AJTFRIOCSA-N

InChi: InChI=1S/C27H30N2O4/c1-3-33-26(32)27-16-8-7-11-23(27)29(25(31)22(27)17-24(30)28-2)18-19-12-14-21(15-13-19)20-9-5-4-6-10-20/h4-6,9-15,22H,3,7-8,16-18H2,1-2H3,(H,28,30)/t22-,27-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 50 mg/mL (111.97 mM; Need ultrasonic). H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Fumarate hydratase-IN-1 inhibits SW620, ACHN, HCT-116, PC3, and SK-MEL-28 cell lines with a mean IC50 of 2.2 μM.

Products are for research use only. Not for human use.

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