Adrenomedullin (AM) (13-52), human


Catalog No. Size PriceQuantity
M30933-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Adrenomedullin (AM) (13-52), human is a 40 amino acid peptide, which acts as an endothelium-dependent vasodilator agent.

Product information

CAS Number: 154765-05-6

Molecular Weight: 546.68

Formula: C31H39FN6O2

Chemical Name: N-{6-cyclopropyl-1-[(2-fluoro-6-methoxyphenyl)methyl]piperidin-3-yl}-3-{imidazo[1,2-a]pyridin-6-yl}-octahydro-1H-indazole-5-carboxamide

Smiles: COC1=CC=CC(F)=C1CN1CC(CCC1C1CC1)NC(=O)C1CC2C(NNC2CC1)C1=CN2C=CN=C2C=C1

InChiKey: XJOVNCGUQXEANC-UHFFFAOYSA-N

InChi: InChI=1S/C31H39FN6O2/c1-40-28-4-2-3-25(32)24(28)18-38-17-22(9-11-27(38)19-5-6-19)34-31(39)20-7-10-26-23(15-20)30(36-35-26)21-8-12-29-33-13-14-37(29)16-21/h2-4,8,12-14,16,19-20,22-23,26-27,30,35-36H,5-7,9-11,15,17-18H2,1H3,(H,34,39)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

The effects of Adrenomedullin (AM) (13-52), human [hADM-(13-52)] are investigated in the rat pulmonary vascular bed and in isolated rings from the rat pulmonary artery (PA). Under conditions of controlled blood flow and constant left atrial pressure when tone is increased with U-46619, injection of hADM-(13-52) produces dose-related decreases in lobar arterial pressure. hADM-(13-52) modulates receptor-mediated, but not voltage-dependent, pulmonary vascular contraction by influencing Ca2+ influx.

Products are for research use only. Not for human use.

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