CM10


Catalog No. Size PriceQuantity
M31026-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

CM10 is a potent and selective aldehyde dehydrogenase 1A (ALDH1A) family inhibitor, with IC50s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM10 does not inhibit any of the other ALDH family members. CM10 can regulate metabolism and has anti-cancer activity.

Product information

CAS Number: 692269-09-3

Molecular Weight: 321.42

Formula: C20H23N3O

Chemical Name: 2-(prop-2-en-1-yl)-6-{[(1-propyl-1H-1,3-benzodiazol-2-yl)amino]methyl}phenol

Smiles: CCCN1C2=CC=CC=C2N=C1NCC1=CC=CC(CC=C)=C1O

InChiKey: ZFHWEWJDCFGRBO-UHFFFAOYSA-N

InChi: InChI=1S/C20H23N3O/c1-3-8-15-9-7-10-16(19(15)24)14-21-20-22-17-11-5-6-12-18(17)23(20)13-4-2/h3,5-7,9-12,24H,1,4,8,13-14H2,2H3,(H,21,22)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 125 mg/mL (388.90 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CM10 (12.5, 25, 50, 100 μM; 1 hour) inhibits ALDEFLUOR activity in live cells and preferentially depletes CD133+ ovarian cancer stem-like cells (CSCs). CM10 induces a cellular/nuclear swelling necroptotic phenotype.

Products are for research use only. Not for human use.

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