Description
CM10 is a potent and selective aldehyde dehydrogenase 1A (ALDH1A) family inhibitor, with IC50s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM10 does not inhibit any of the other ALDH family members. CM10 can regulate metabolism and has anti-cancer activity.
Product information
CAS Number: 692269-09-3
Molecular Weight: 321.42
Formula: C20H23N3O
Chemical Name: 2-(prop-2-en-1-yl)-6-{[(1-propyl-1H-1,3-benzodiazol-2-yl)amino]methyl}phenol
Smiles: CCCN1C2=CC=CC=C2N=C1NCC1=CC=CC(CC=C)=C1O
InChiKey: ZFHWEWJDCFGRBO-UHFFFAOYSA-N
InChi: InChI=1S/C20H23N3O/c1-3-8-15-9-7-10-16(19(15)24)14-21-20-22-17-11-5-6-12-18(17)23(20)13-4-2/h3,5-7,9-12,24H,1,4,8,13-14H2,2H3,(H,21,22)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 125 mg/mL (388.90 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
CM10 (12.5, 25, 50, 100 μM; 1 hour) inhibits ALDEFLUOR activity in live cells and preferentially depletes CD133+ ovarian cancer stem-like cells (CSCs). CM10 induces a cellular/nuclear swelling necroptotic phenotype.
Products are for research use only. Not for human use.
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