CL2A


Catalog No. Size PriceQuantity
M31039-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

CL2A is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker.

Product information

CAS Number: 2616704-22-2

Molecular Weight: 1062.21

Formula: C50H79N9O16

Chemical Name: N-[(1-{26-[2-({[(1S)-5-amino-1-{[4-(hydroxymethyl)phenyl]carbamoyl}pentyl]carbamoyl}methoxy)acetamido]-3,6,9,12,15,18,21,24-octaoxahexacosan-1-yl}-1H-1,2,3-triazol-4-yl)methyl]-4-[(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl]cyclohexane-1-carboxamide

Smiles: NCCCC[C@H](NC(=O)COCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCN1C=C(CNC(=O)C2CCC(CN3C(=O)C=CC3=O)CC2)N=N1)C(=O)NC1C=CC(CO)=CC=1

InChiKey: CJDCJOXHKQMGGB-DBSIFAAZSA-N

InChi: InChI=1S/C50H79N9O16/c51-14-2-1-3-44(50(66)54-42-10-6-40(36-60)7-11-42)55-46(62)38-75-37-45(61)52-15-17-67-19-21-69-23-25-71-27-29-73-31-32-74-30-28-72-26-24-70-22-20-68-18-16-58-35-43(56-57-58)33-53-49(65)41-8-4-39(5-9-41)34-59-47(63)12-13-48(59)64/h6-7,10-13,35,39,41,44,60H,1-5,8-9,14-34,36-38,51H2,(H,52,61)(H,53,65)(H,54,66)(H,55,62)/t39?,41?,44-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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