Description
DC_C66 is a cell-permeable, selective coactivator associated arginine methyltransferase 1 (CARM1) inhibitor with an IC50 of 1.8 μM. DC_C66 has a good selectivity for CARM1 against PRMT1 (IC50=21 μM), PRMT6 (IC50= 47μM), and PRMT5.
Product information
CAS Number: 108181-00-6
Molecular Weight: 404.48
Formula: C28H22NO2
Chemical Name: 26-(ethoxycarbonyl)-25λ⁵-azahexacyclo[12.12.0.0²,⁷.0⁸,¹³.0¹⁶,²⁵.0¹⁷,²²]hexacosa-1(26),2,4,6,8,10,12,14,16(25),17,19,21-dodecaen-25-ylium
Smiles: CCOC(=O)C1=C2C3=CC=CC=C3C3=CC=CC=C3C2=CC2C3=CC=CC=C3CC[N+]=21
InChiKey: DIVJVPWHSSAIPN-UHFFFAOYSA-N
InChi: InChI=1S/C28H22NO2/c1-2-31-28(30)27-26-23-14-8-7-12-21(23)20-11-5-6-13-22(20)24(26)17-25-19-10-4-3-9-18(19)15-16-29(25)27/h3-14,17H,2,15-16H2,1H3/q+1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
DC_C66 (6.25-100 μM; 24-72 hours) exhibits antiproliferation activity in several CARM1-associated cancer cell lines.
Products are for research use only. Not for human use.
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