Description
GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM.
Product information
CAS Number: 2055015-61-5
Molecular Weight: 419.38
Formula: C16H16F3N3O5S
Chemical Name: 3-amino-N-[(2S)-2-hydroxypropyl]-5-[4-(trifluoromethoxy)benzenesulfonyl]pyridine-2-carboxamide
Smiles: C[C@H](O)CNC(=O)C1=NC=C(C=C1N)S(=O)(=O)C1C=CC(=CC=1)OC(F)(F)F
InChiKey: UMOGNCVNHXWFIX-VIFPVBQESA-N
InChi: InChI=1S/C16H16F3N3O5S/c1-9(23)7-22-15(24)14-13(20)6-12(8-21-14)28(25,26)11-4-2-10(3-5-11)27-16(17,18)19/h2-6,8-9,23H,7,20H2,1H3,(H,22,24)/t9-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 250 mg/mL (596.12 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
GLPG2451 has an EC50 value of 675 nM and an efficacy level of 147% of that of VX770 in G551D/F508del cells.
Products are for research use only. Not for human use.
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