FM26


Catalog No. Size PriceQuantity
M31924-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

FM26 (compound 25) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM. FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells.

Product information

CAS Number: 2407981-35-3

Molecular Weight: 461.82

Formula: C22H15ClF3N3O3

Chemical Name: 4-[({3-[2-chloro-6-(trifluoromethyl)phenyl]-5-(1H-pyrrol-3-yl)-1,2-oxazol-4-yl}methyl)amino]benzoic acid

Smiles: OC(=O)C1C=CC(=CC=1)NCC1C(=NOC=1C1=CNC=C1)C1=C(Cl)C=CC=C1C(F)(F)F

InChiKey: KGEONJPJJNFHOI-UHFFFAOYSA-N

InChi: InChI=1S/C22H15ClF3N3O3/c23-17-3-1-2-16(22(24,25)26)18(17)19-15(20(32-29-19)13-8-9-27-10-13)11-28-14-6-4-12(5-7-14)21(30)31/h1-10,27-28H,11H2,(H,30,31)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

FM26 (compound 25; 10 μM, 24h) significantly reduces IL-17a mRNA expression 27-fold in EL4 cells.

Products are for research use only. Not for human use.

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