Description
FM26 (compound 25) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM. FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells.
Product information
CAS Number: 2407981-35-3
Molecular Weight: 461.82
Formula: C22H15ClF3N3O3
Chemical Name: 4-[({3-[2-chloro-6-(trifluoromethyl)phenyl]-5-(1H-pyrrol-3-yl)-1,2-oxazol-4-yl}methyl)amino]benzoic acid
Smiles: OC(=O)C1C=CC(=CC=1)NCC1C(=NOC=1C1=CNC=C1)C1=C(Cl)C=CC=C1C(F)(F)F
InChiKey: KGEONJPJJNFHOI-UHFFFAOYSA-N
InChi: InChI=1S/C22H15ClF3N3O3/c23-17-3-1-2-16(22(24,25)26)18(17)19-15(20(32-29-19)13-8-9-27-10-13)11-28-14-6-4-12(5-7-14)21(30)31/h1-10,27-28H,11H2,(H,30,31)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
FM26 (compound 25; 10 μM, 24h) significantly reduces IL-17a mRNA expression 27-fold in EL4 cells.
Products are for research use only. Not for human use.
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