DC07090 dihydrochloride

DC07090 dihydrochloride is a low toxicity, potent, reversible and competitive non-peptidyl human enterovirus 71 3C protease inhibitor with an IC50 and a Ki value for 21.72 μM and 23.29 μM. DC07090 dihydrochloride could also inhibit coxsackievirus A16 (CVA16) replication with an EC50 value of 27.76 μM.

Product information

CAS Number: 1158264-37-9

Molecular Weight: 375.25

Formula: C18H16Cl2N4O

Chemical Name: 4-{[1,3]oxazolo[4,5-b]pyridin-2-yl}-N-[(pyridin-2-yl)methyl]aniline dihydrochloride

Smiles: Cl.Cl.C(NC1C=CC(=CC=1)C1=NC2=NC=CC=C2O1)C1=CC=CC=N1

InChiKey: NLHMKUDAEGGODS-UHFFFAOYSA-N

InChi: InChI=1S/C18H14N4O.2ClH/c1-2-10-19-15(4-1)12-21-14-8-6-13(7-9-14)18-22-17-16(23-18)5-3-11-20-17;;/h1-11,21H,12H2;2*1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

DC07090 dihydrochloride forms stable hydrogen-bonding interactions with the main chains of S128, G145, G164 and hydrophobic interactions with F25, L125, L127 and F170. DC07090 dihydrochloride (0.01~10 μM) shows micromolar potency against EV71 3Cpro. DC07090 dihydrochloride exhibits a highly inhibitory potency on EV71 replication with an EC50 value of 22.09 μM. DC07090 dihydrochloride inhibits CVA16 with an EC50 value of 27.76 μM.

Products are for research use only. Not for human use.