Sappanchalcone


Catalog No. Size PriceQuantity
M32009-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells.

Product information

CAS Number: 94344-54-4

Molecular Weight: 286.28

Formula: C16H14O5

Chemical Name: (2E)-3-(3,4-dihydroxyphenyl)-1-(4-hydroxy-2-methoxyphenyl)prop-2-en-1-one

Smiles: COC1=CC(O)=CC=C1C(=O)/C=C/C1=CC(O)=C(O)C=C1

InChiKey: JVGNTXGHBHMJDO-QHHAFSJGSA-N

InChi: InChI=1S/C16H14O5/c1-21-16-9-11(17)4-5-12(16)13(18)6-2-10-3-7-14(19)15(20)8-10/h2-9,17,19-20H,1H3/b6-2+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Sappanchalcone has a statistically significant effect on HCT116 cells than on SW480 cells (IC50= 37.33 μM and 54.23 μM, respectively). Sappanchalcone reduces MMP with a significant increase in ROS levels in human colon cancer cells. Sappanchalcone triggered phosphorylation of p53, which is involved in the activation of caspases and increased expression of Bax in HCT116 cells.

Products are for research use only. Not for human use.

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