Indophagolin


Catalog No. Size PriceQuantity
M32016-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7.

Product information

CAS Number: 1207660-00-1

Molecular Weight: 523.75

Formula: C19H15BrClF3N2O3S

Chemical Name: 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-cyclopropanecarbonyl-2,3-dihydro-1H-indole-6-sulfonamide

Smiles: O=C(C1CC1)N1CCC2=CC(Br)=C(C=C12)S(=O)(=O)NC1=CC(=C(Cl)C=C1)C(F)(F)F

InChiKey: OGXJZCDFFBDSJJ-UHFFFAOYSA-N

InChi: InChI=1S/C19H15BrClF3N2O3S/c20-14-7-11-5-6-26(18(27)10-1-2-10)16(11)9-17(14)30(28,29)25-12-3-4-15(21)13(8-12)19(22,23)24/h3-4,7-10,25H,1-2,5-6H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (477.33 mM; Need ultrasonic and warming).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Indophagolin (10 μM) inhibits autophagosome formation in MCF7 cells.

Products are for research use only. Not for human use.

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