Description
Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7.
Product information
CAS Number: 1207660-00-1
Molecular Weight: 523.75
Formula: C19H15BrClF3N2O3S
Chemical Name: 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-cyclopropanecarbonyl-2,3-dihydro-1H-indole-6-sulfonamide
Smiles: O=C(C1CC1)N1CCC2=CC(Br)=C(C=C12)S(=O)(=O)NC1=CC(=C(Cl)C=C1)C(F)(F)F
InChiKey: OGXJZCDFFBDSJJ-UHFFFAOYSA-N
InChi: InChI=1S/C19H15BrClF3N2O3S/c20-14-7-11-5-6-26(18(27)10-1-2-10)16(11)9-17(14)30(28,29)25-12-3-4-15(21)13(8-12)19(22,23)24/h3-4,7-10,25H,1-2,5-6H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 250 mg/mL (477.33 mM; Need ultrasonic and warming).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Indophagolin (10 μM) inhibits autophagosome formation in MCF7 cells.
Products are for research use only. Not for human use.
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