Propargyl-PEG4-5-nitrophenyl carbonate


Catalog No. Size PriceQuantity
M32155-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Propargyl-PEG4-5-nitrophenyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 1422540-81-5

Molecular Weight: 397.38

Formula: C18H23NO9

Chemical Name: 4-nitrophenyl 3,6,9,12-tetraoxapentadec-14-yn-1-yl carbonate

Smiles: C#CCOCCOCCOCCOCCOC(=O)OC1C=CC(=CC=1)[N+]([O-])=O

InChiKey: BRQWRLYCHVNDKS-UHFFFAOYSA-N

InChi: InChI=1S/C18H23NO9/c1-2-7-23-8-9-24-10-11-25-12-13-26-14-15-27-18(20)28-17-5-3-16(4-6-17)19(21)22/h1,3-6H,7-15H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.

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